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Male circumcision and HIV infection
Oct 31, 2005

I just can't quite grasp the positive correlation between male circumcision and HIV infection. Why is a circumsized male at less risk than uncircumsized?

Response from Dr. Wohl

I do not think that the exact mechanism is understood. Possible explanations include the collection of mircoorganisms beneath the foreskin that can provoke and inflammatory repsonse. This response includes white blood cells that can harbor HIV. The foreskin may also be subjected to abrasions during or following sex that may also act as a portal for HIV transmission.


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