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High liver enzymes

Oct 17, 2005

pos for 22 years. My doctor stopped my meds after taking for 4-5 years.cd4 went down by half to 309 and viral load went up to over 50,000. tested liver 3 times and it is 179. she wants me to have an ultrasound and wants to start a new regimen. What has caused my liver enzymes to go so high. I was taking Zerit, epivere and Ziagen.

Response from Dr. Pierone

The list of possible causes of a jump in liver tests is fairly extensive, but there are some repeat offenders that are worth mentioning. The first is viral hepatitis infection and this usually can be readily ruled out with blood testing. Another possibility is drug induced toxicity. Sometimes HAART (especially triple nucleoside therapy) can produce mitochondrial toxicity that interferes with liver cell function. This may occur later in the course of therapy after years of cumulative exposure to ARVs. If the ultrasound is negative and liver tests remain high off therapy some clinicians would pursue a liver biopsy, but others would simply choose a different regimen. A nuke-sparing combination would be reasonable thing to do in a situation like yours. Thanks for posting and let us know how things turn out, good luck!

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