|RE What to do - Aptivus
Oct 11, 2005
Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations (especially re Viread) but the phenotype and virtual phenotype show sensitivity. Can it be that the Viread can be effective? I'd like to start on 3TC, Viread (or another eg Ziagen) and Sustiva and save T20, Aptivus/rt for later. The pharmactist in my doctors office is pushing me to take T20, Aptivus, Sustiva, 3TC, Ziagen, AZT. I guess my main question to you is what the significance of the TAMs are if the drug is showing on phenotype as "sensitive". What would you do? Thanks. Mike
| Response from Dr. Pierone
It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous post it is very likely that you would respond to a combination of Viread, 3TC, and Sustiva despite the mutations noted. The TAMs in question 41, 210 can affect sensitivity to Viread, but when present in 3 or more (you have 2, the T215S does not count). This would be a much simpler choice than an Aptivus-based regimen. Hope that this help and best of luck!
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Is Itchy Scrotum A Sign Of HIV?
- Ache In Testicles After Giving Handjob Worried I Have HIV
- Burning Urethra After Having Sex During Period Worried I Have HIV
- Flu Symptoms After Giving Handjob Worried I Have HIV
- Itchy Skin After Deep Kissing Sign Of HIV AIDS
- Sore On Tongue After Sex With Hooker Worried I Have HIV
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.