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Choosing Your MedsChoosing Your Meds
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Sep 21, 2005

I been Hiv+ since 1985.Recently I was off med for 4 months due to my recent relapse. Back in recovery CD4 250 VL25000.Also type 2 Diabetic[due to viracept]In April when i was taking viramune videx and Viread Genotype shows that I am resisstant to Delaverdine,Sustiva and Viramune. I ask my doctor to put me on Rayataz/ truvada/Norvir.But He put me on Rayataz/Norvir/Epzicom.Because he think Truvada whold mess with my liver Because of my Diabities. What is your take on that and what i can expect from this cobination. After 20 years quality of life is more important then quantity. Thank You

Response from Dr. Young

Thanks for your post.

The combination of Epzicom, Norvir and Reyataz should be a reasonable one for you. The resistance testing suggest that you only had resistance to the non-nuke part of your previous regimen, leaving the nukes and PIs as fully potent (at least in principle). There are well characterized side effect profiles of these medications (and are well described in other posts on the forum as well as other pages of In brief, the only major issue with Epzicom is the risk of developing an allergic reaction to the abacavir component. This reaction can be quite serious if the diagnosis is delayed, though in our hands has not been a major deterrent to using this otherwise very well tolerated medication. Essential to this is making sure that you've got a good lines of communication with your doctor. Norvir/Reyataz likewise is usually very well tolerated, with minimal gastrointestinal side effects. The characteristic side effect of this combo is the development of icterus or jaundice (yellowing of the eyes and skin). Usually mild, these skin changes sometimes abate (especially if you stay well hydrated), but on occasion in our clinic have necessitated changing the protease inhibitor.

Overall, I'd expect your quality (and quantity) of life to be very good on this regimen.

Good luck, good health. BY

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