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nukes vs non nukes
Aug 21, 2005

I work for an ASO and I I get question all the time and I need a simple answers. Can you please tell me the differnce between a nukes and non-nukes and must PHA's take at least one class of the meds? Steve

Response from Dr. Young

Thanks for your post.

There is a wealth of information about these medications here at TheBody.com.

In brief, nukes are nucleoside reverse transcriptase (RT) inhibitors(include AZT,d4T, ddI, 3TC, FTC, abacavir and with a minor caveat, tenofovir). The medications bind to the active site of HIV RT and are nearly always part of combination therapies, in combination with either a non-nuke (see below) or protease inhibitors.

Non-nukes, or non-nucleoside RT inhibitors include the medications nevirapine and efavirenz. These drugs also inhibit RT, but do so by binding to a different part of the viral enzyme. Many first-line treatments for HIV include combinations of nukes and non-nukes.

All recommended first-line treatment combinations for HIV now include three or four drugs from two drug classes, but as noted above, but acceptable regimens can be constructed with non-nukes or PIs as noted above.

Hope this helps. BY



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