The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

. . . and then what next

Jun 28, 2005

Doctor, given my earlier posting, if the resistance tests results hold and its assumed I'm still good for Sustiva, what do you recommend I do, having lost Viread (and possibly 3TC)? Can I add Viramune to the combo? How about the new protease inhibitor? I suppose T20 is an option too but not crazy about having to inject . . . any advice you could offer would be appreciated. Thanks very much.

Response from Dr. Young

Thanks again-

Based on your resistance tests and the Stanford HIV resistance database, one might predict that your virus is indeed quite resistant to first-line drugs.

The Stanford interpretation of your virus' mutations looks like this:

APV Intermediate resistance ATV High-level resistance IDV High-level resistance LPV High-level resistance NFV High-level resistance RTV High-level resistance SQV High-level resistance

Drug Resistance Interpretation NRTI Resistance Mutations: M41L, V118I, L210W, T215S NNRTI Resistance Mutations: None

RT Other Mutations: 43Q, 211K

Nucleoside RTI 3TC Potential low-level resistance ABC Intermediate resistance AZT Intermediate resistance D4T Intermediate resistance DDI Intermediate resistance FTC Potential low-level resistance TDF Intermediate resistance

These would suggest I would be trying to build a potent regimen around a NNRTI (like efavirenz or nevirapine), perhaps in combination with tipranavir (though drug interactions can be a problem) or T20. In cases like yours, I try to obtain a phenotypic resistance test to provide further clarity about your existing options.

Good luck again, BY

What to do . . .

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint