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which combination is more understanding with adherance?

Jun 21, 2005

thank you for your help...i love reading through this Q and A section... i would like to know which combination is more flexible if i am late taking my medication some say two, three, four hours? viramune/epzicom or sustiva/truvada? Does the half life of these pills have anything to do with it? thank you for your help

Response from Dr. Pierone

Both of these regimens would be expected to be very forgiving of a several hour delay in a dose. This is based on the long persistence of these agents in the bloodstream and inside cells. Truvada (Viread + Emtriva) would be expected to have active levels longer than Epzicom (Ziagen + Epivir). Likewise, Sustiva should outlast Viramune in the body. The greater concern is completely forgetting to take the medication for an entire day (or longer - it happens). This is the situation in which longer lasting medications might be expected to be superior. Hope that this helps and thanks for posting.

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