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rr in nc
Jun 5, 2005

can the combo of kaletra and combivir cause lysodstrorph

Response from Dr. Wohl

Sure can. Major concerns would be for lipid changes mostly secondary to the Kaletra. The whole abdominal girth increase is hard to peg on a single agent but does seem more of a problem with protease inhibitors and there is nothing to suggest Kaletra is immune. The AZT in Combivir can cause fat loss although not nearly as much as d4T does.

However, the risk of major body shape changes, I would say, is pretty low and the potency of this regimen high.

Alternative first line therapies could include tenofovir+3TC or FTC+atazanavir+ritonavir or same nucleosides plus efavirenz if metabolic problems are truely a major fear.

DW



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