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Sustiva, Truvada & Serequel

May 7, 2005

I've been taking Sustiva & Truvada for 6 weeks and have been experiencing severe depression. I am concerned about how these drugs are interacting with the other medications I take on a daily basis; resperdal .05 mg, Effexor 300 mg, Ritalin 20 mg 2x daily, Serequel 50mg at night. I am especially concerned about the Serequel which I use to help me sleep. My stomach is upset frequently and overall I feel down and depressed. I think I'm taking too many drugs and should discontinue everything to give the Sustiva & Truvada a chance. Can you give me some feedback about the interactions of these drugs?

Response from Dr. Pierone

There is no question that HIV therapy (Sustiva in particular) can exacerbate depression. I would discuss this issue with your clinician and psychiatrist as soon as possible so that they can put together some recommendations. It does not seem wise to stop the medications for depression, my instinct would be to stop (or modify) the Sustiva and Truvada regimen. This depends on your viral load and CD4 counts prior to initiation of therapy. Hope that this helps.

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