The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Re: CCR5 and CXCR4
Apr 15, 2005

Dr. Whol, At what CD4 counts do people go from CCR5 to CXCR4?

If you have crossed that line, are there therapies that combine the two to look forward to?

Furthermore, if that number is great than 350, it's a shame people are instructed to wait until then to go an therapy.

What are your thoughts?

Response from Dr. Wohl

There is no cut off CD4 cell count at which this occurs. I have a patient with a CD4 cell count of 90 who just entered a study of a CCR5 blocker and had only CCR5 tropic virus. There is a tendency for there to be more CXCR4 tropic virus the lower the CD4 cell count.

Whether the advent of CCR5 blockers will influence when we start therapy, we will see. There are really good reasons that therapy is delayed. Plus, as mentioned at counts of 350 or so CCR5 tropic virus is common.



  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint