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Reyetaz is it a P.I. or a non-nuke?
Mar 30, 2005

I would like to know if grapefruit and it's juice,malabsorbe Reyetaz?

Response from Dr. Young

Atazanavir (Reyataz) is a protease inhibitor, not a non-nuke. The drug requires an acidic environment in the stomach to be optimally absorbed-- as such, the medication should be taken with food and patients should not use potent stomach acid-lowering medications, like omeprazole.

Grapefruit juice has some potential to interact with protease inhibitors, by decreasing the rate of elimination (not absorption) of the medications (tby interfering with liver metabolism), but this effect is, in general, small. Because grapefruit juice is acidic in nature, I don't expect that there should be a significant interactdion with atazayanvir. BY



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