I've been on once daily sustiva/Truvada for 5 months with great results and only one troublesome side-effect: The mild dizziness & generally "odd" feeling I get one hour after taking sustiva at 11pm, pretty much makes any evening activity challenging, whether it involves going out, reading, typing, etc. If I eat ANYTHING (not just high-fat) within 1 hour of taking it, I'm totally down for the night. What is generally swapped in, if I decide that I don't want to continue Sustiva? I also tend toward high cholesterol and there is also the lipid issue on Sustiva and it's diminishing effect on Lipitor. Is it ever adviseable to take only truvada at 11pm and delay sustiva until i'm ready to go to sleep at 12, 1am, 2am?

There are several choices available. First is to delay Sustiva until just before bed as you have described. The second is to check a baseline blood level of Sustiva and then lower the dose to 400mg (2 200mg capsules) and monitor for improvement in side effects and adequacy of follow up blood levels. Another option is to switch to Viramune, this is easier on cholesterol, but has a greater chance of liver toxicity. One could also switch to a protease inhibitor-based therapy, but this would be lower on the list. Hope that this helps.