I have been on a HAART regimen which includes Kaletra for a few years now but have NOT had a treatment failure. For a number of reasons (liver toxicity, pill burden, etc.) I have been considering changing to Reyataz. Everything I have read about Reyataz, however lumps people who have taken HIV drugs in the past with people who have experienced a drug failure. Thus, if I ultimately decide to switch, should I start the regime of Reyataz with boosted Norvir (for treatment failure patients) or the once a day regime without Norvir (for treatment naive patients); OR should I give up the idea entirely, since recent studies tend to suggest that Kaletra is not that much more toxic for the liver than Reyataz, and since conventional wisdom suggests that one should not change whores in mid stream?

I am not sure about whores, but it definitely not advisable to changes horses in midstream (due to the drowning risk if ones boot gets caught in the stirrup). That said, it is ok to switch HIV medications with the goal to limit toxicity while maintaining virologic control. If there is no resistance to protease inhibitors, then you may get away with unboosted Reyataz. Our team rarely uses unboosted Reyataz because we feel the addition of a relatively low dose of Norvir transforms Reyataz into a very potent agent. So switching is ok, but it really depends on the specifics of you case. Best of luck to you!