|Cocktail for drug resistant virus
Dec 28, 2004
I had a break of 16 months from anti-retroval treatment since I couldn't handle the Crixivan. During the break I had a tonsillectomy.My counts worsened to a CD4 of 250 (from 580) and viral load of 115 000 (from 20 000). My new HIV specialist recommended a cocktail that include Kaletra, Invi-rase, Viread and Ziagen. I did only a bit of reading on these drugs and have the following questions: (a) Do any of these drugs pass the into the brain area and if not, is it criticial to add/replace for a drug that is effective - unfortunately drug resistance tests showed resistence to many drugs in the non-protease-inhibitor classes (excl fusion inhibitor) although I was not taking all of these drugs when the test was conducted (b) I read that there is an improved drug in place of the Invirase would it be better to replace Invirase with this drug although I understand that Invirase in combination with one of the Kaletra composites (c) Any general comment on the recommended combination. Would really appreciate response. Thanx (Have been HIV+ for 6 years)
| Response from Dr. Pierone
These antiviral medications do cross into the brain in more than sufficient amounts to prevent viral replication in the central nervous system. I am not sure what medication you read about in place of Invirase, but the most sensible regimen really depends on the results of previous resistance tests. I can say that Invirase is often used in combination with Kaletra in situations where there is multi-drug resistant virus. This regimen is very potent, but not that well tolerated due to gastrointestinal side effects. There are some experimental protease inhibitors that also work for multi-drug resistant virus Tipranavir and TMC-114. Tipranvir is nearing approval within the next 6 months. Hope this helps, good luck to you.
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.