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Time to Start Treatment?
Sep 18, 2004

I had my 3 month appointment with my HIV doctor today. I was diagnosed 7/12/2002 (just after my 22nd birthday, though I know my infection date to be 4/18/2002 for certain), and have thus far avoided treatment. My CD4 % has slowly dropped from 27 to 23%, and has been hovering between 20 and 22% for the last year and a half now. My Viral load has been all over the map from as high as287,000 to as "little as" 29,500, with absolutely no consistency between visits. My CD4 has been up and down, and for the second in a row, has been down, from 399 to 320. So, I've hit below the magic "350" threshold, and I'm now considering treatment options. The doc seems to think that since my CD4 percentage is still at 20% and my total lymphocyte was only 1600, it may not be so unusual that my CD4 absolute count would have gone down. However, I'm not so convinced. I've requested another set of labs, which I will go in for on Saturday, and if my CD4 absolute is still below 350, I want to start treatment. My question is two parts: as a doctor, would you also recommend more labs showing results below 350, and go more by the CD4%, would you have started treatment earlier, or recommend it now? Also, if I start treatment next month, what therapy would you recommend. My doctor mentioned a new combo pill of a two drug, once daily treatment, that could be taken in conjunction with Sustiva, for a 2 pill, once a day treatment. I want something powerful, yet manageable, as I fully understand the importance of adherance.

At 24yo, and postive for two years, I am hoping my numbers to rebound quickly (hopefully a CD4% up to 35-40% with CD4 absolute between 640-1100, since I started with 792.)

Sincerly, Painfully Pondering ...

Response from Dr. Lee

Clearly you have many options for therapy. It is best to work with your doctor to fit your life-style and other medical problems, family history of medical problems, etc. with a therapy that you will tolerate well and be able to sustain over the long haul. Just about any of the combinations that utilize two nucleosides and either a non-nuc or a protease inhibitor work very well if you are able to take them regularly.

Be well.

AZT Anemia
Struggling Tcell count

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