The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

Replication capacity

Sep 9, 2004

What exactly is meant by replication capacity and how can this be tested? Has this become an important part of HIV care??? Can you explain. I have been infected with HIV for 15 years and this is the first I heard of this.

Response from Dr. Pierone

Replication capacity is a measure of how efficiently HIV can grow (or replicate) in experimental conditions. There are a several methods of testing for this viral attribute, but the most common means is through a resistance test called Phenosense GT, commercially available from Virologic.

When viral resistance develops to antiretroviral agents, the replication capacity of this resistant virus often declines. This is the only good thing about viral resistance. The most appropriate role for replication capacity is not yet known. For patients that do not have drug resistance and have undetectable viral load on therapy the test is not relevant. The main way that I use replication capacity is to reassure me if I have made a decision to continue a patient on a regimen that is showing viral breakthrough, but with stable CD4 counts. In a case like this a replication capacity of 3 percent lends support to my clinical suspicion that this is a significantly weakened virus. Ongoing studies should clarify the larger role of this testing in clinical practice and at this point it is not an essential test, but it is definitely a very interesting one.

I need urgent opinion tipranavir
It is not always the Videx

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint