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treatment with drugs-Kaletra, Abacavir, &Tenofovir

Sep 6, 2004

I have a friend who is HIV positive and is considering starting a treatment program that includes the medications Kaletra, Abracavir and Tenofovir. What can you tell me about their effectiveness and possible side effects? Thank you so much.

Response from Dr. Pierone

These are 3 of the most commonly used HIV medications, but it is not that common for abacavir (Ziagen) to be used in combination with tenofovir (Viread) in first line therapy due to lack of data and better options. The main toxicities with Kaletra include diarrhea and metabolic complications (diabetes, lipid elevations). Viread is generally well tolerated. Ziagen is a good drug, but may produce hypersensitivity reaction during early therapy, which may be severe. All 3 drugs are effective, although Kaletra is the most potent agent. Thanks for posting.

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