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Prednisolone for HIV
Sep 6, 2004

Dear Dr Pierone.

I read with great interest your article about use of prednisolone for slowing down loss of t4-cells in some patient groups. As a newly infected (autumn 2003) person with viral load in the area of 2000 (tested january and march 2004) and t4 1000-1200 (no HAART), do you think i should talk to my HIV-specialist about starting with prednisolone?

Yours, Thomas

Response from Dr. Pierone

I reported on this study with interest because over the years I have had a few patients with HIV infection that required corticosteroids for other reasons and I also noticed that they seemed to do well with a remarkably stable course. In fact, in my pile of potential studies to do I had a folder labeled 'prednisone and HIV'.

But a few anecdotal cases and a retrospective, uncontrolled trial simply set the stage for a prospective controlled trial to see if this potential therapy is for real. So prednisolone therapy should be considered experimental and is not ready for prime time. Stay tuned though.

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