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Norvir/Grapefruit Interactions
Sep 5, 2004

I was reading that there is a potential harmful food drug interaction for people taking Norvir. Neither my Dr, nor pharmacist mentioned this. I do take norvir and consume grapefruits and grapefruit juice almost daily. I have not noticed any negative side effects. Would I, or is this something that only blood workup will reveal. I've stopped eating grapefruits until I have a chance to discuss with my Dr. But I wanted to get the "Experts'" opinion as well.

Response from Dr. Young

Thanks for your question.

Grapefruit juice (in extremes) can cause alterations in some drug levels, particularly in some medications metabolized by the liver. Because ritonavir (Norvir) and other protease inhibitors are metabolized by the same pathways as grapefruit juice, their combined use should be done with some modest caution. It's likely that the grapefruit juice will increase the levels of the protease inhibitors that your taking, perhaps causing some excessive side effects or lab toxicities.

You're unlikely to have any symptoms of this, but if your taking a Norvir-boosted PI, I'd certainly let your doctor know about the amount of grapefruit juice that you're consuming.

Thanks for reading. BY



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