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Avoid Ziagen if VL > 100,000
Jul 2, 2004

Dear Doctor(s):

Thank you for the service, information and assistance you are providing here.

In "25 Things You Should Know if You Are HIV-Positive" in this website (, point #8 says, "If your viral load is greater than 100,000, avoid Viracept or Ziagen as the 'anchor' medication in your regimen."

Can you please let me know why Ziagen is to be avoided under this circumstance?

Response from Dr. Pierone

This simply means that you would not use a triple nucleoside regimen (like Trizivir alone) for high viral load. It would not be a problem to use Ziagen as one of the medications, just not the anchor. For example, Ziagen, Epivir, and Sustiva would be fine.

first PI based and then switch to NNRTI?
Starting treatment with a subtype

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