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Update On SMART study?
May 4, 2004

Hey Gerald! I'm doing great... and thanks for all your help! A couple months ago my doc mentioned some of his patients are doing STI's....and they are doing great (I think they did this on their own.. but told him...he doesn't really push them). Since I can't access the SMART site (no ID) can you give us an idea how things are going? Is there any "current" info you can link us to to read? thanks!

Response from Dr. Pierone

The SMART public web site is down right now while they are updating it (hurry up guys!). The study is going well, enrollment is climbing (1849 patients as of today) and eventually 6000 people will be enrolled worldwide.

This study randomizes people with HIV infection and CD4 count above 350 to either continuous antiretroviral therapy (with goal to keep virus suppressed) or CD4 count driven STI strategy. The latter group has medications put on hold until CD4 count drops below 250 cells and then continues treatment until CD4 count goes above 350 cells. This will lead to cycles of antiretroviral therapy for this group (with a considerable amount of time off medication). It will likely be years before we see which group does better. From our perspective as an investigative site, both groups are doing well with no major problems seen. But the night is young.



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