PI Pill Burden
Mar 7, 2004
Dear Dr Young
My question is about PI based therapy for those resistant to NNRTIs. Is there any future hope that the pill burden may be reduced ? Will Kaletra for example always require at least 6 pulss/day or will there be new PIs coming out that will help reduce pill burden?
Response from Dr. Young
Thanks for your question.
News Flash: Pill burden for protease inhibitors has been reduced.
Kaletra represented the first of a newer set of protease inhibitors-- it reduced pill counts (as you point out) to three pills twice daily. There's not need to hope for lower pill burden, low pill burden PIs are already here.
Last year, two new PIs, atazanavir (Reyataz) and fosamprenavir (Lexiva) were approved for use in the US. Used with ritonavir boosting, the total pill counts (including the ritonavir) are 3 and 4. Unboosted, the pill burdens are 2 (for taz) and 4 (for fosamprenavir). Together, the pill burden for these new PIs are essentially the same as the initial pill burden for the highly successful NNRTI, efavirenz (Sustiva).
Thanks for reading. BY
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