HIV-2: any tried and true HAART regimens?
Jan 5, 2004
Dr, Pierone, How many drugs have been approved for treatment of HIV? Of these, how many are NNRTI's?
I am asking, because I was stunned to have been diagnosed with HIV-2 (especially because I was infected in the US! I know that there are various drug regimens tried and proven for HIV-1 and the HHS Department has recommended frontline regimens, such as Combivir and Sustiva or Viread, Epivir and Sustiva/Viramune.
Are there tried and proven regimens for HIV-2? Could you recommend some specific drug combinations that have been shown effective in treating HIV-2 (for example, is there a potent one that includes Viread and Epivir?). I am quite scared that, because HIV-2 gets scant research, we patients will have drug regimens used that are unproven...and because there are no VL tests for HIV-2, we wouldn't know if there is drug resistance).
Can you please help out and advise whether there are established and proven effective drug regimens for HIV-2? (I just know that non Nukes like Sustiva and Viramune cannot be used).
Hoping to hear from you.
Response from Dr. Pierone
Hello, as you may know, HIV-2 tends to progress more slowly than HIV-1, so you may not need treatment for some time depending on how your numbers turn out. Getting a viral load for HIV-2 used to be a problem, but is now available commercially.
There are limited data on treatment of HIV-2, but clearly protease inhibitor-based therapy is effective for treatment of HIV-2. There are some caveats with the protease inhibitors - amprenivir is ineffective (so Lexiva would presumably not work as well), nefinavir (Viracept) may not be active based on a position 77 mutation in the protease gene.
So, if you do require treatment, it should be a boosted protease regimen with 2 nukes. My thoughts would be either Kaletra, Viread, Epivir or Reyetaz/ritonavir, Viread, Epivir. As a disclaimer, please realize that I have not ever treated HIV-2, but base these suggestions from the limited treatment information that is available. Good luck!
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.