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heart disease associated with PI therapy
Jan 4, 2004

Dr. Dave,

What is not good news is that heart attacks have become to take more notice then longer an individual is on PI therapy according to a recent study. How is science working to change and fix this?


Response from Dr. Wohl

A recently reported study did indeed describe an increase in the rate of heart attacks in people taking combination HIV therapy. This is a serious finding although similar results have not been seen in other studies. And, it should be noted that the total number of heart attacks detected in this study was about 130 out of over 25,000 people. Still concern is certainly warranted.

What is being done? First of all, I think HIV docs have become much more savvy about screening patients for lipid and glucose abnormalities. Second, many are prescribing lifestyle modifications and lipid lowering therapy when needed. Third, newer drugs without adverse lipid effects are coming on line. Lastly, many are trying to understand why certain lipids go up with therapy, what role the drugs, the virus, the immune system and genetics play in these abnormalities and how can they be predicted and prevented.

I am optimistic we will come up with answers as well as better treatments. DW

treatment at seroconversion
Now, not Later!

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