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what is going to be the next major hiv breakthrough?
Dec 30, 2003

Dr. Gerald,

What is going to be the next major hiv breakthrough, something that will revolutionize hiv therapy and secure it by taking it to the next level, a positive advancement? What is your outtake on this?

Regina

Response from Dr. Pierone

It is hard to know where the next HIV breakthrough is going to come from. So many companies and investigators are working on HIV worldwide. It may simply be a series of incremental advances rather than a dramatic breakthrough. There are exciting vaccine based approaches and new entry inhibitors that have tremendous promise.

One of the most interesting new agents is TNX-355, a humanized monoclonal antibody directed against the CD4 domain that is given by intravenous infusion. At 2003 Retrovirus a study was presented that showed a one time infusion was safe and led to greater than a 1 log reduction in viral load that persisted for several weeks. Have not heard a peep since then but I assume more work has been done. Stay tuned.



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