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Combivir and Videx
Dec 12, 2003

(CD4 307, VL 33k, Treatment has not yet started.)

Are Combivir and Videx a good combination for initial HIV treatment? One doctor said "not really," another doctor said, "definitely not," and a third prescribed the drugs. (Another question made reference to this problem, but the answer was not clear.)

Would Combivir and Abacavir (i.e., Trizivir) be an optimal combination?

Or should an NNRTI like Sustiva also be specifically requested?

Response from Dr. Pierone

The use of a triple nucleoside combination for treatment of HIV infection is not really the best regimen based on available studies. However, there are many patients that have been on triple nuke therapy for years and have done great with controlled virus and no problems.

Comparative studies have shown the NNRTI-based therapy tend to result in a higher rate of patients with controlled virus than triple nuke regimens. So the DHHS treatment guidelines have recommended NNRTI-based therapy as preferred over triple nucleoside combinations.



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