Nov 25, 2003
If given the following three options for intial therapy which would you choose or recommend, if any? Please help with this decision. Thanks for helping in advance.
2. LPV/RTV+2 NRTIS
3. EFV+2 NRTIS
| Response from Dr. Pierone
I would favor either number 2 or 3 (although option 1 certainly works). Choice of initial therapy depends on the needs and characteristics of the individual person being treated. Option 3 is the most popular initial choice because it is easier to take and has an excellent track record. However, for people with adherence challenges there is potential for early virologic failure because resistance to efavirenz (Sustiva) just takes one viral mutation. Resistance to Kaletra requires multiple mutations for resistance and this is the attribute (along with its potency) that influences many physicians to use it up front despite the greater pill burden and metabolic problems.
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.