Since starting a Combivar/Sustiva regimen 5 weeks ago my previously flagging appetite has returned with a vengence. I am constantly hungry and eat in greater volume and more often than ever before. My weight has stabalized. Yet my BMs only occur every 3-4 days! I used to be a very regular and frequent guy. Will taking a laxative interfere with the meds?

Probably not. I'd try to avoid chronic laxative use, however, as it can eventually make things worse. Look to see if anything else you are taking can be doing this. Next look at your diet. Does it contain fiber? If not you may want to use mother nature's own products (green veggies, figs, nuts etc). Enough dietary fiber should work wonders for you and your regularity. Can't stand fruits and vegetables? Over the counter fiber agents (e.g Metamucil) should help. I would try not to take these fiber supplements with your meds and instead wait a couple of hours after your HIV meds.

Also, if you are at all lactose intolerant this may be a good excuse to eat some previously forbidden dairy.

If all the above do not help, talk to your doctor. A more complete medical work up for thyroid or other ailments may be in order. DW