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FTC and lipoatrophy?
Oct 29, 2003

Dr. Young,

Is FTC one of the drugs considered a high risk for lipoatrophy? If so or not, which are, and which do you avoid perscribing?

Tyler

Response from Dr. Young

Thanks for your question.

Most experts believe that injury to the cell's mitochondria (a cellular organ responsible for manufacturing energy) correlate with risk of lipoatrophy. As such, the fact that d4T causes mito injury and risk of lipoatrophy are internally consistent.

FTC (emtricitabine, Emtriva) is a new nucleoside medication that actually causes (in the test tube) very little, if any mitochondrial injury. Because of this, it is expected that FTC should cause little drug-associated risk of lipoatrophy. BY



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