NEVER GOT AN ANSER FROM THE BODY
Oct 22, 2003
Hi, I have placed my question three times and never been answer and I really need advise: I've been HIV+ since 1983, never been sick and my TCell count has always been over 800 and my viral load always undetected. I'm on Crixivan, Epivir and Zerit. I belive Zerit is contributing to my wasting of my face and hips, and I want to switch Zerit only since I heard Zerit contributes to Lipo. Can you advise on a substitute for Zerit and continue to take Crixivan and Epivir? Thanks Antonio
Response from Dr. Pierone
Hi and sorry about not getting back to you sooner. We have been behind on answering questions and are trying to get caught up.
The regimen you are on was a favorite of mine from many years ago. But that's the issue, it's a regimen whose time has come and gone and can be easily improved. Substituting tenofovir (Viread) for Zerit is the most common choice to help with fat wasting. If you are having any problems with Crixivan, that could be changed as well. Crixivan can cause kidney stones, abdominal protuberance, lipid issues, and tendency for diabetes. If you are doing well on it (in fairness, some people have no problems with it) and don't want to change no problem.
Another larger question is whether you should just take a break from HIV medications for a while and see how things go. There was a recent study from ICAAC meeting link that looked at people with high CD4 counts that took a structured treatment interruption. Those that had high nadir CD4 counts (like you) are doing very well off medications.
Good luck and let us know how things go.
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