|resistance as a treatment option
Sep 20, 2003
dear MD Could a drug be found or even exist that could suppress the hiv virus but if it broke through and became resistant, the mutation would make it unable to replicate.We know that some mutations render the virus 'less fit' ie M184V but could there be a mutation that selects for self destruction.A therapy that suppresses while active and renders incapable when resistant to seems a winner.Any chance of a nobel prize!!?
Response from Dr. Young
There are data that suggest that viruses that are less replicatively fit may cause less immunological damage-- but if I were to balance the benefits of having a potent drug vs less fit, I vote for the potent drug.
Either way, virus that is less fit is still able to replicate and still able to cause CD4 cell damage.
Having been around Nobel prize winning work, it is heartening to know that people like you are thinking outside the lines for novel ideas; perhaps we just haven't stumbled onto the right mutational approach yet. BY
early HIV & optic neuropathy
What do you think?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.