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resistance as a treatment option
Sep 20, 2003

dear MD Could a drug be found or even exist that could suppress the hiv virus but if it broke through and became resistant, the mutation would make it unable to replicate.We know that some mutations render the virus 'less fit' ie M184V but could there be a mutation that selects for self destruction.A therapy that suppresses while active and renders incapable when resistant to seems a winner.Any chance of a nobel prize!!?

Response from Dr. Young

There are data that suggest that viruses that are less replicatively fit may cause less immunological damage-- but if I were to balance the benefits of having a potent drug vs less fit, I vote for the potent drug.

Either way, virus that is less fit is still able to replicate and still able to cause CD4 cell damage.

Having been around Nobel prize winning work, it is heartening to know that people like you are thinking outside the lines for novel ideas; perhaps we just haven't stumbled onto the right mutational approach yet. BY



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