|Question on Drugs
Sep 20, 2003
Dear Dr. Young,
I have a couple questions about possible new treatments for HIV. Perhaps they will be under discusison years forum now in thsi forum?
1. Ampligen; in Phase III, it also has shown potential for chonic fatigue?
2. ALVAC-MN 120TMG; devloped by Aventis Pastuer, I am not sure what it is going to do but herralded as being a new class of drugs. Phase II.
3. REMUNE; described as HIV immunogen. interesting research and development history. Phase III.
Thanks for your thoughts.
| Response from Dr. Young
Thanks for your question. There are a number of ongoing immune based therapies under study. I'm not in any way considered to be an immunologist, but here are some updates.
You've listed some of the old guard: Ampligen has seen some initial interest as an immune modulator. It is a double-stranded RNA, thought to stimulate the immuns system. Early results caused some excitement, but a FDA-reprimand letter should give all reading press release-based reports pause: http://www.pharmcast.com/WarningLetters/July2000/Hemispherx0700.htm. I haven't personally seen recent data from the company, but studies suggest that there is immune-based activity in persons off antiretroviral therapy-- how much and how valuable remains to be seen.
ALVAC-MN120 is a vaccine-based approach from Aventis-- most recent news from this company is a collaboration with Merck to test vaccine strategies for HIV (see: http://www.aventis.com/main/page_s.asp?pageid=41490145991686957172&lang=en).
Remune development has been halted in the US, though there may be some ongoing research activity in Thailand. (See this link for details http://www.thebody.com/tpan/septoct_01/remune.html)
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