Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  Breaking News: FDA Approves Triumeq, New Once-Daily Combination Pill
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


meds for starin o???
Sep 14, 2003

Doctor Pierone, it's me again... Could you please, find out what are the medicinesthat work against hiv rare strain 0(Cameroon)? Is it true that this starin is more virulent? Please, knowing that this strain is rare, take your time for researching informations about it, but answer me! Forgive my bad English. Hoping to read your answer, thanks a lot. Miss Sadness

Response from Dr. Pierone

Miss Sadness, your English is much better than my Cameroonian so please don't fret. I have researched group O HIV as per your request and am here to report.

First, as a refresher, HIV worldwide is divided into 2 species, HIV-1 and HIV-2. HIV-2 made the jump to humans from African green monkey (sooty mangabey) and is mainly located in Central Africa. HIV-1 is responsible for the vast majority of human infection and was transmitted to humans from Chimpanzees.

HlV-1 is divided into 3 groups, M for major, O for outlier, and N for non M/non O (this makes sense). The great majority of infections worldwide are group M, which has 9 pure subtypes A-K (A to D, F to H, J, and K). Group O occurs mainly in central and west central Africa, but rare cases have been reported in Europe and the U.S (linked to transmission from central Africa).

The Cameroon (your favorite watering hole) is distinguished by harboring both group N and O types of HIV. There is wider diversity of HIV infection the Cameroon than just about anywhere else in the world (please don't ask me why, I just treat patients in Florida).

I was not able to find any studies that suggest that group O is more aggressive or virulent than non-group O virus. However, similar to HIV-2, there are studies that suggest that group O virus is resistant to non-nucleoside reverse transcriptase inhibitors (Sustiva, Nevirapine). So in the case of infection with group O protease inhibitor-based therapy should be used. Hope this helps. GP



Previous
Which specific symptoms will cause you to recommend HAART if CD4 count is normal and VL undetectable?
Next
Thanks

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement