|Summer 2003 Update: Next 5 Hiv Drugs Nearing Approval
Aug 1, 2003
What are the next five hiv drugs nearing the pipeline and coming to approval?
| Response from Dr. Young
My crystal ball has never been very accurate--(and I'm not sure why you picked the next "five" products as your subject).
This has been a big year for new HIV products already, with the approval(or distribution) of fusion inhibitor-enfuvirtide (T-20, Fuzeon), protease inhibitor-atazanavir (Reyataz) and nucleoside-emtricitabine (FTC, Emtriva).
Further down the pipeline, things get more difficult to predict. First off there are new agents of existing classes, like the PI tipranavir and TMC114; new fusion inhibitor T-1249. Further down the list (and earlier in drug discovery) are a number of new nukes, non-nukes and protease inhibitors.
Perhaps generating additional interest are candidate compounds representing new drug targets-- clearly therapeutic vaccines are of interest, HIV integrase inhibitors and new entry inhibitors, such as CCR5 inhibitors either have started human clinical trials or will start in the near future.
Overall, the pipeline continues to mature with additional products and drug targets. This is exciting times, but should be tempered with the knowledge that not all products in the pipeline make it into real drugs (indeed, only 1 of 3 drugs in phase 1 or phase 2 trials actually get approved). These are enormous projects, requiring huge investments in money, committment and volunteer time-- let's hope that we continue to have the drive to continue to improve our therapeutic options.
Thanks for the question. BY
ps-- please, please only post your question once.
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