Factors CAUSING RESISTANCE
Jul 22, 2003
Is resistance only or usually caysed by people missing doses? Or does also or often occur because the virus "learns" how to beat the drug? Does anyone know the statistics regarding what percentage of resistance develops from missed doses, and what percentage is due to virus "smarts" or other factors? Also, how many years on average does a drug work before resistance develops?
Response from Dr. Wohl
There are a bunch of reasons viral resistance develops including poor absorption, cellular mechanisms that pump drugs out of the cell, drug interactions, and, yes, sub-optimal adherence.
It seems that poor adherence is the leader of the pack as a cause of drug failure and resistance, although it is not always easy to detect some of the other culprits.
Most studies that have measured adherence have found sobering results, with less than ideal adherence being fairly common. Among those who do stay faithful to their regimen, long term (years) suppression of the virus is often observed.
If you take 99-100% of your doses and develop resistance, it was one of these other reasons or that you were unfortunate enough to acquire a virus that was already resistant to HIV meds. DW
Get Email Notifications When This Forum Updates or Subscribe With RSS
- What To Take To Suppress Genital Herpes?
- What Reactions Does Genital Herpes Have?
- What Is The Life Span Of A Person Infected With Herpes?
- What Do Shingles Look Like When They First Start?
- Risk Using No Condom When One Partner Has Herpes But Not On An Outbreak
- Symptoms Of Advanced Syphilis
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.