Jul 5, 2003
I think it may be a cure if we use 3 PIs or 1 PIs plus 2 fusion inhibitor as HAART. The theory is that NRTI inhibited cell is still alive because a single virus can not kill the cell. The infected cell starts to work again even there is no virus at all. However when it reaches the stage of PI inhibition, the infected cells are already dead. Therefore, it may be a cure if we use normal HAART for half year then suddenly change to 3 PIs or any HAART without NRTIs for several months, then it maybe a cure because we not only destroys the virus but also the infected cells ( the infected cell is destroyed by the virus itself)...
Response from Dr. Young
Thanks for your comments-- While your strategy has not been tested, the primary issue with the inability to eradicate the virus lies with the fact that some cells (latently-infected T cells) remain HIV infected for many years-- in order to eradicate the virus, fully suppressive therapy needs to be sustained for decades.
timeline for resistance testing
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