HI,

In reference to the question about 100 adherence, does that mean if the patient never misses a dose and achieves undetectable viral loads and continues never to miss a dose that the medication could work indefinately?

Yes, I believe that if someone is 100% adherent and has an undetectable viral load that the medications could work indefinitely. There are many people that have been undetectable and still going strong ever since highly active therapy was originally introduced.

Of course no one can predict the future, but it seems counterintuitive that someone would be undetectable for virus for 5 years, never miss a dose, and then the virus breaks through at year seven. Also, as a bonus, given the pace of medical progress in HIV therapy newer regimens will surely become less toxic and more potent.