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toxoplasmosi and rashes with low bloodcount
Mar 29, 2003

hi with cd 4 at 40 i had toxplasmosis.two months i took daraprim 50 mg daily and dalacin 1800 mg daily.i developed a rash after one month and after 2nd month.i have to start triterapy soon but am scared of damage.Should it be better to just lower the doses or stop altogether before starting?My tongue feels like burned cold lika the doctors anestesy. i am not sure where it comes from:could be from medication or txo? it cuts my appetite.Today I left daraprim cuz i had to much a rash...I dont know what to do,can i quit the treatment safeley? How long do i have to wait to start antivirals?which do you recommend? Where does tingles in my tongue come from?hope you can inspiire me thank you very much m from belgium

Response from Dr. Young

Thank you for your question--

I'd agree with your doctor about starting on triple antiviral therapy for HIV in the near future. While it might appear that you have a drug allergy to Daraprim, this should not affect your ability to tolerate HAART treatments. Which drugs to start is a lengthy subject; assuming that you have wild-type, or drug susceptible virus, most US-based clinicicans would start a regimen of two nucleosides (ZDV/3TC, tenofovir/3TC are popular) with a non-nucleoside (like nevirapine or efavirenz) or with a boosted protease inhibitor (typically, Kaletra).

Treatment for toxoplasmosis should be continued in one way or another until your CD4 count is reproducibly greater than 100 cells and your asymptomatic.

Hmm, inspiration. I'd share with you the idea that current medication regimens can be very well tolerated and very potent, provided that they are taken with excellent adherence. I have many patients who initially presented with very low CD4 counts who are now doing very well, with functional immune reconstitution and few, if any side effects of medications.

The best thing to do is to work very closely with an experienced HIV clinician, get good clinical and laboratory monitoring. Good luck, BY

Post-exposure prophylaxis side effects minimization

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