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How many combos a person has?

Mar 21, 2003

Dear docs, how many combos a person has after begining treatment (considering development of drug resistence)? How many times is it possible to switch till I run out of options? Robert

Response from Dr. Young

Robert, thanks for your question.

The answer to the question depends a lot on how treatments are managed. In general, a second- and probably third-round regimen should be sucessful, provided that the resistance pattern is well understood and the interventions are appropriate. Deeper "salvage" therapies can be sucessful, only that the likelihood decreases. Newer classes of medications (like fusion inhibitors or integrase inhibitors) should permit improvements in the prognosis for these persons too.

This is a key area of debate and research- that is, the proper sequencing of antiretroviral therapies. Good luck, BY

no treatment at all for 2 years
Drastic CD4 decrease

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