Mar 19, 2003
If it is said that treatment failure occurs when HIV mutates into resistant strains, are you saying that a mutant inhibitor-resistant form of HIV is able to produce functional virus?
If so, are there any examples in scientific literature which show persons with functional mutant strains of HIV?
| Response from Dr. Young
I'm not totally clear about your question, but there a plenty of examples of mutant, drug-resistant virus in the literature.
Indeed, one functional measure of mutant virus is the ability to cause new infections-- the trend for increasing amounts of initial HIV infections with drug resistant virus are increasing world wide, representing as many as 1 in 4 new cases in San Francisco and 1 in 10 in the United States. For a reference on the subject, see S. Little, New England Journal of Medicine, 2002. -BY
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