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Drug Resistance
Mar 19, 2003

If it is said that treatment failure occurs when HIV mutates into resistant strains, are you saying that a mutant inhibitor-resistant form of HIV is able to produce functional virus?

If so, are there any examples in scientific literature which show persons with functional mutant strains of HIV?

Response from Dr. Young

I'm not totally clear about your question, but there a plenty of examples of mutant, drug-resistant virus in the literature.

Indeed, one functional measure of mutant virus is the ability to cause new infections-- the trend for increasing amounts of initial HIV infections with drug resistant virus are increasing world wide, representing as many as 1 in 4 new cases in San Francisco and 1 in 10 in the United States. For a reference on the subject, see S. Little, New England Journal of Medicine, 2002. -BY



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