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Methotrexate and HIV
Mar 7, 2003

I am HIV+, not yet on medication, with viral load, 90,000 and C4 at 340. Otherwise, completely healthy, no thrush, night sweats, loss of weight, etc. Question is I take 7.5mg (once a week--very low dose)of methotrexate for an autoimmune condition. Is this a threat to my overall health, especially as it relates to HIV, because I could switch to something else, or give it up all together (not sure how effective it is as it is for an autoimmune ear condition which has been stable for six years). Please let me know your thoughts on this. Thanks in advance.

Response from Dr. Wohl


Methotrexate is an immune system suppressant. Even in persons without HIV infection, this drug can increase the risk of certain infections. Therefore, the drug could potentially exacerbate the immunosuppressive effects of HIV.

Additionally, as you know, methetrexate can have some side effects, in particular liver toxicity. Some HIV drugs can also injure the liver so your clinician would have to be mindful of your use of this drug when prescribing medications to fight HIV.

If you and your clinician feel you can do without the methetrexate (? for relapsing polychondritis?), then that may be the best option. Otherwise, if in the risk to benefit analysis you need to stay on this agent, I think your HIV doc can work around it and keep you out of danger. DW

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