Jan 19, 2003
Dear Dr. Young:
I wrote to you very recently about a friend who has a CD4 count of 50. I recently learned that his viral load is 482. Given his low CD4 count, this seemed very low to me. What does this disparity mean? I also found out that he is taking a combination of Combiver and Kaletra. Is this a strong enough combination of drugs for him? He has MAC, a small, persistent lingering of pnemonia, which he has had for a couple months, and he also has eosinophilic dermatitis (sp?). Given all this, do you believe he is being treated correctly? I hear so often about people who don't receive the proper potency of drugs to combat HIV/AIDS. Many thanks for your first response.
Response from Dr. Young
Thanks for your question.
Would seem that your friend is on appropriate and very potent first-line treatment for HIV. The potentcy of some drugs appears to diminish among persons with very low CD4 cell counts (like <50), but Kaletra-based regimens don't appear to be affected much by this.
One should also expect that your friend is receiving multiple drug therapy to treat his M. avium (MAC) infection.
Yes, the viral load would appear to be low for a treatment naive person with such advanced disease, but either way, points out that HIV (at any viral load) still can cause significant immune depletion. It might be the case that the viral load that you've cited actually reflects a viral load obtained after the initiation of treatment-- if this is the case, interpretation would require knowing what the baseline viral load was.
Hope this helps, BY
Absorption...Can it lead to resistance?
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