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Absorption...Can it lead to resistance?

Jan 19, 2003

In a recent search on the net, I saw that fatty AND/OR high protein meals can decrease rate and extent of absorption of zidovudine in Trizivir. Can this lead to or speed the rate of drug resistance? Is slowing of absorption an matter for concern? This is a concern since I find that I am better able to deal with the medication if I talk each dose with a meal. Thanks for your time!

Response from Dr. Young

Dietary issues don't seem to affect the potency of Trizivir- clearly having lower drug levels might be a point of concern, but it has been our practice to not instruct patients about meals and Trizivir.

Hope this helps, BY

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