|New products; any news ?
Aug 22, 2002
Is there any new information about second generation nnrti's that can hold out against resistance to the current class? If so how far in the future before you think they would be available for public consumption(fda approved)? Also how about intergrase inhibitors?Thank you
| Response from Dr. Young
Thanks for your questions.
There are a couple of so-called second-generation NNRTIs in the pipeline; these products are still some time away from large scale, pivotal studies. Two to watch are Tibotec's TMC125 compound and capravirine, from Agouron/Pfizer. FDA approval, if all goes well could still be a couple or three years away.
As for integrase inhibitors, two companies (Merck and Shionogi/GSK) have candidate compounds that have entered early human clinical trials (Phase I or Phase II). Preliminary efficacy data from these trials might still be 6-12 months away, and yet an additional 2-3 years before pivotal studies are completed.
Stay tuned, these compounds could very well be very important drugs in the years to come. -BY
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