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THE NEXT 5 HIV DRUGS?
Aug 17, 2002

Hiya Experts, Thank you for you work as always. I was wondering what are the next five hiv drugs that will be approved? What should we the public keep our eyes on? When can we expect these? And most importantly, do these drugs offer hope to newly acquired HIV infections with resistance to multiple drug strains (Infections acquired in 2002)? Finally, do any of these drugs look less toxic than those that are out today? Thanks a million.

Very truly yours,

Norman

Response from Dr. Young

Thanks for your questions-

There are a number of products that are near approval- In the next 6 months: Extended Release stavudine (Zerit XR)- a once-daily verson of stavudine T-20- the first HIV fusion inhibitor

In the next 1-2 years (hopefully)- Atazanavir - a once daily protease inhibitor GW908- an improved cousin of the protease inhibitor amprenavir

Further off- second generation NNRTIs second generation protease inhibitors (tipranavir) with improved resistance profiles

Way further off- vaccines other fusion inhibitors

Yes, each new drug carries it's own set of unique properties- either improved toxicity or dosing frequency; for others, improve activity in resistant virus.

Hope this is helpful. BY



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