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acyclic
Jun 6, 2002

I don't know if this requires a long and complicated answer, but what does acyclic mean relating to "acyclic nucleotide" in the case of tenofovir? Thank you

Response from Dr. Young

Thanks and sorry for the possible confusion.

This relates to the chemical structure of tenofovir, particularly in reference to the other nucleoside analogues. Naturally occuring nucleosides (or nucleotides) are composed of a base (the Watson-Crick A,C,T or G's) attached to a cyclic (shaped in a ring) sugar- like ribose or deoxyribose (this is the "R" in RNA or the "D" in DNA).

Tenofovir differs from the natural nukes (and many of the other HIV drugs) in that there is no cyclic sugar group. Instead, there is a non-cyclic chemical group that fills the structural place of the sugar group. This structural difference has been proposed as part of the basis of tenofovir's resistance profile.

Hope this helps to clarify. BY



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