Jun 6, 2002
I don't know if this requires a long and complicated answer, but what does acyclic mean relating to "acyclic nucleotide" in the case of tenofovir? Thank you
Response from Dr. Young
Thanks and sorry for the possible confusion.
This relates to the chemical structure of tenofovir, particularly in reference to the other nucleoside analogues. Naturally occuring nucleosides (or nucleotides) are composed of a base (the Watson-Crick A,C,T or G's) attached to a cyclic (shaped in a ring) sugar- like ribose or deoxyribose (this is the "R" in RNA or the "D" in DNA).
Tenofovir differs from the natural nukes (and many of the other HIV drugs) in that there is no cyclic sugar group. Instead, there is a non-cyclic chemical group that fills the structural place of the sugar group. This structural difference has been proposed as part of the basis of tenofovir's resistance profile.
Hope this helps to clarify. BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.