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nnrti side effects
May 26, 2002

Can nnrti cause lactic acidosis? Besides a rash, what else are they known for?Do you think they block hiv better than nrti's and are equivelent to pi's or are pi's still at the top of the suppressor "heap"?

Response from Dr. Young

NNRTIs are not known to cause lactic acidosis. The side effects of the medications include liver toxicity (nevirapine>efavirenz)and neuropsychiatric (efavirenz). In general, the class of medications is very well tolerated and potent.

Potency is roughly equivalent to protease inhbitors and the most potent NRTIs (depends on which drugs you compare). Equivalency is a more difficult question to answer, since other factors-- potency, tolerability (side effects and toxicity) and adhereability figure into the equation. BY



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