May 23, 2002
Which drugs in the na class(including tenofovir)have the least about of mitochondrial toxcity VS. the most,or are they all pretty much the same?
Response from Dr. Young
Thanks for the question.
The issue of mitochondrial toxicity has gain a lot of recent attention. It is clear that mitochondrial toxicity is associated with lactic acidosis, pancreatitis, and certain types of muscle injury; there is conjecture (though pretty strong) that there may be association with other types of toxicities (lipodystrophy, for example).
The nucleoside/nuecleotide inhibitors differ with regard to their relative mitochondrial toxicities. Recent data (Birku, 9th Conference on Retroviruses, 2002) supports the idea that tenofovir, abacavir and lamivudine (3TC) cause the least amount of injury. Other nucleosides cause increasing amounts of injury (as measured by mitochondrial DNA levels): AZT< d4T< ddI < ddC.
I hope this is helpful, BY
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