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2 non nukes
May 11, 2002

Do you ever recommend a triple combination with 2 NNRTI's. Since resistance to 1 often wipes out the entire class wouldnt it be beneficial to use 2 of thse medications together to utilize the most options/resources available? or would this be considered a single drug combination? Are there issues of over-dosing for 2 NNRTIs in the same class? Are there any studies with this combination. Just a thought, I'm sure someone would have thought of it before me.

Response from Dr. Young

Thanks for your question.

You do raise an interesting point about resistance; however, there is scant data that supports the simultaneous use of NNRTIs together. Indeed, since the drugs compete for the same binding site, there is reason to think that there would be very little additive effect of dual NNRTI-based therapy.

Perhaps in the future, with NNRTIs with different resistance patterns or binding sites to the reverse transcriptase, we might be able to exploit dual NNTRIs. BY



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